GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12196860 | 1 | rs4336432 | chr6:55946490 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs7116495 | 1 | rs4338555 | chr11:71755696 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs4338740 | 1 | rs4338740 | chr15:49735297 | DTWD1 | chr15:49913226-49937332:+ | -0.17 | -3.98 | 7.9E-5 | Thyroid volume |
| THCA | cis | rs4338740 | 1 | rs4338740 | chr15:49735297 | GALK2 | chr15:49447976-49622002:+ | 0.17 | 3.74 | 0.000206 | Thyroid volume |
| THCA | cis | rs4338740 | 1 | rs4338740 | chr15:49735297 | SECISBP2L | chr15:49280967-49338630:- | 0.16 | 4.48 | 9.29E-6 | Thyroid volume |
| THCA | cis | rs4338740 | 1 | rs4338740 | chr15:49735297 | SLC27A2 | chr15:50474393-50528588:+ | 0.21 | 3.4 | 0.000735 | Thyroid volume |
| THCA | cis | rs4332428 | 1 | rs4341440 | chr10:4965293 | AKR1C2 | chr10:4964715-5060207:- | 0.3 | 3.97 | 8.28E-5 | Height |
| THCA | cis | rs751728 | 1 | rs4342423 | chr6:33732679 | LEMD2 | chr6:33738991-33756906:- | -0.3 | -6.8 | 3.22E-11 | Crohn's disease |
| THCA | cis | rs10816533 | 1 | rs4344199 | chr9:99549449 | FAM22G | chr9:99690592-99704572:+ | 0.84 | 7.08 | 5.04E-12 | Height |
| THCA | cis | rs10816533 | 1 | rs4344199 | chr9:99549449 | HIATL2 | chr9:99695549-99775862:- | 0.6 | 5.1 | 4.83E-7 | Height |
| THCA | cis | rs10816533 | 1 | rs4344199 | chr9:99549449 | NCBP1 | chr9:100395705-100436027:+ | -0.29 | -3.85 | 0.000135 | Height |
| THCA | cis | rs6748734 | 1 | rs4344931 | chr2:241818527 | C2orf54 | chr2:241825466-241835573:- | 0.3 | 6.57 | 1.29E-10 | Urinary metabolites |
| THCA | cis | rs7894051 | 1 | rs4345885 | chr10:135191311 | ECHS1 | chr10:135175988-135186908:- | 0.52 | 7.16 | 3.05E-12 | Lifespan |
| THCA | cis | rs3771570 | 1 | rs4346380 | chr2:242263223 | ANO7 | chr2:242127924-242164791:+ | 0.38 | 4.33 | 1.85E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs4346380 | chr2:242263223 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.09 | 5.0E-5 | Prostate cancer |